Two sample MR report
HLA-DQA2_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | -0.0976404 | 0.1220028 | 0.4390867 |
| Weighted median | 14 | 0.0197509 | 0.0169844 | 0.2448765 |
| Inverse variance weighted | 14 | 0.0271214 | 0.0126525 | 0.0320680 |
| Simple mode | 14 | 0.0195997 | 0.0294031 | 0.5166935 |
| Weighted mode | 14 | 0.0195997 | 0.0272892 | 0.4853302 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.843767 | 12 | 0.8677630 |
| Inverse variance weighted | 7.900877 | 13 | 0.8499974 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0940331 | 0.0914578 | 0.3241543 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000115 | 0 | TRUE | 0.3087507 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
